A stable effervescent tablet, granule or powder composition free from excipients that may react with an effervescing organic acid component, comprising: an effective amount of a antidiabetic drug, an effervescing organic acid component, an effervescing base component buffers, to modulate gastric pH after ingestion, essentially free of sodium wherein said composition is completely solubilised within 5 minutes without stirring in 3 to 8 fluid ounces of water at between 5 - 20 ℃.本發明提供一種可與發泡有機酸組分反應的不含賦形劑之穩定發泡錠劑、顆粒或粉末組成物,其包含:有效量之抗糖尿病藥物,發泡有機酸組分,發泡鹼組分;基本上不含鈉的緩衝劑,其用以調節攝食後之胃的pH;其中在5℃至20℃之間,在不攪拌情況下,該組成物在5分鐘內完全溶解於3液盎司至8液盎司水中。
