INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA
发明人:
ZHONG, BOHUA,HE, XINHUA,WANG, YONGGUANG,LIU, HE
申请号：
EP10835359
公开号：
EP2511281A4
申请日:
2010.06.21
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
An acyclic nucleoside phosphonate derivative and medicine use thereof are provided. In detail, an acyclic nucleoside phosphonate derivative shown in formula I is provided, which has potent antiviral activity (such as hepatitis B virus activity) and less cytotoxicity, and pharmaceutically-acceptable salts, isomers, hydrates or solvates thereof, where, R1 is selected from H or methyl each R2 is independently selected from -R3 or -OR3 and each R3 is independently selected from C1-C8 alkyl or C3-C8 cycloalkyl. A preparation method of the compounds shown in formula I, a pharmaceutical composition containing the compounds, and a medical application thereof are also provided. The acyclic nucleoside phosphonate derivative is effective for antivirus, such as hepatitis B virus, and is good in vivo behavior attributes.
