The present invention relates to it is a kind of detect fluid specimen sample analysis instrument (1) measuring chamber (2) in grumeleuse method, wherein the fluid specimen sample analysis instrument (1) include at least two analyte sensors (3,4): the first analyte sensor is used to measure the first analyte in liquid sample With one or more second analyte sensors, it is used to measure the second analyte of one or more of described liquid sample in the measuring chamber It the described method comprises the following steps: (a) at least partly filling the measuring chamber (2) with known solution, the known solution has the composition of the one or more of first analyte comprising predeterminated level and predeterminated level second analyte, (b) First ray of measurement result is obtained by first analyte sensor, and at the same time obtaining the second sequence of measurement result by one or more second analyte sensors, (c) variation of the First ray of measurement result is determined, (d) variation of second or more the sequence of measurement result is determined, (e) compare the variation of the First ray of measurement result and second sequence of measurement result, (f) it determines based on the comparison in the measuring chamber with the presence or absence of grumeleuse.
