WONG, Oi Kwan,CHOU, Joyce Ching,DUSSEAUX, Mathilde Brunnhilde,SMITH, Julianne
申请号：
SG11201805872S
公开号：
SG11201805872SA
申请日:
2017.01.10
申请国别(地区):
SG
年份:
2018
代理人:
摘要：
The invention provides Chimeric Antigen Receptors (CARs) that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making thereof, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for using these CARs and engineered immune cells for the treatment of EGFRvIII-mediated pathologies, including cancers such as glioblastoma.
