Systems are disclosed which include processor-executable program instructions for receiving data regarding characteristics of a room and determining, based on the received data, operating parameter/s for one or more disinfection sources to disinfect the room. The data may include data regarding non-physical characteristics and/or physical characteristics of the room. In some embodiments, data regarding a quantity and/or type of at least a subset of the plurality of disinfection sources for disinfecting the room may also be considered for determining the operating parameter/s. In any case, the determined operating parameter/s may include a run time of a disinfection source, a position of a disinfection source within the room, a speed at which a disinfection source moves throughout the room, an orientation of a component comprising a disinfection source, a rate of germicidal discharge from a disinfection source and/or power supplied to a disinfection source.