In one of the most important aspect of the invention topical composition of Chitosan nanoparticles and Tinospora cordifolia as combination is provided for the treatment of Acne Vulgaris, the skin cream is prepared from the combination of an effective amount of Chitosan nanoparticles, alcoholic extract of Tinospora cordifolia along with pharmaceutically acceptable excipients Further an effective amount for the inhibition of propionibacterium acne is obtained The ratio of the combination of an effective amount of Chitosan nanoparticles, alcoholic extract of Tinospora cordifolia is also determined
