Youssef Jounaidi,Stuart Forman,Keith Miller,Joseph F. Cotten
申请号：
US16302001
公开号：
US20200316118A1
申请日:
2017.05.19
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Fusion proteins comprising IL2 and IL2Rβ (e.g., CIRB), IL2, IL2Rβ and IL21R (e.g., CIRB21), and/or comprising IL2, IL2Rβ, and CD28 (e.g., CIRB28)； natural killer (NK) cells that express the fusion proteins and methods of use thereof, e.g., to treat subjects with cancer； and regulatory T cells (T-regs) that express a fusion protein comprising IL2, IL2Rβ, and CD28 and methods of use thereof, e.g., to treat subjects with autoimmune disease or GVHD.
