PROCÉDÉ DE PRODUCTION DE PROTÉINES RECOMBINANTES DÉPENDANTES DE LA VITAMINE K

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专利权人:

Aptevo BioTherapeutics LLC

发明人:

申请号：

EP10827499.4

公开号：

EP2494040B1

申请日:

2010.10.28

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

Methods for producing cell lines with high levels of biologically active recombinant vitamin K dependent proteins are described. The transfected cell lines do not include heterologous genes for processing enzymes and are not subject to selection pressure such as methotrexate resistance. Cell lines producing Factor VII/VIIa and Factor IX are described. These cell lines can be used for isolation of Factor VII/VIIa and/or Factor IX for treatment of Hemophilia.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/