Problem to be solved is to offer anti hepatitis B virus medicine of the new mechanism.Hsa-mir-1185-5p,Hsa-mir-4456Hsa-mir-4446-5p,Hsa-mir-6133Hsa-mir-519c-3p,Hsa-wr-302-c-3pHsa-mir-548c-3p,Hsa-mir-4681Hsa-mir-4633-5pHsa-let 7d-5p,Hsa-mir-42-5p,Hsa-mir-1827Hsa-mir-519b-3p,Hsa-mir-455-5p,Hsa-mir-1275Hsa-mir-548ao - 3PHsa-mir-620Hsa-mir-4661-3p,Hsa-mir-766-5p,Hsa-mir-322-5p,Hsa-mir-4755-5p,Hsa-mir-520bHsa-mir-6505-5p,Hsa-mir-4493Hsa-mir-4737Hsa-mir-519a-3p,Hsa-mir-520 HHsa-mir-4443Hsa-mir-520c-3p,Hsa-mir-1298Hsa-mir-1224-5p,Hsa-mir-4272Hsa-mir-2467-3p,Hsa-mir-550g,Hsa-mir-4690-5pHsa-mir-1294A nucleic acid containing an array of microRNAs selected from the group consisting of hsa-mir-4699-5p and hsa-mir-5197-5p is an active ingredientAnti hepatitis B virus medicine is provided.新しい機序の抗B型肝炎ウイルス薬を提供することを課題とする。hsa-miR-1185-5p、hsa-miR-4456、hsa-miR-4446-5p、hsa-miR-6133、hsa-miR-519c-3p、hsa-miR-302c-3p、hsa-miR-548c-3p、hsa-miR-4681、hsa-miR-4633-5p、hsa-let-7d-5p、hsa-miR-432-5p、hsa-miR-1827、hsa-miR-519b-3p、hsa-miR-485-5p、hsa-miR-1275、hsa-miR-548ao-3p、hsa-miR-620、hsa-miR-4661-3p、hsa-miR-766-5p、hsa-miR-382-5p、hsa-miR-4755-5p、hsa-miR-520b、hsa-miR-6510-5p、hsa-miR-4493、hsa-miR-4737、hsa-miR-519a-3p、hsa-miR-520h、hsa-miR-4443、hsa-miR-520c-3p、hsa-miR-1298、hsa-miR-1224-5p、hsa-miR-4272、hsa-miR-2467-3p、hsa-miR-520g、hsa-miR-4690-5p、hsa-miR-1294、hsa-miR-4699-5p及びhsa-miR-5197-5pからなる群より選択されるマイクロRNAの配列を含む核酸を有効成分とする、抗B型肝炎ウイルス薬が提供される。
