OREGON HEALTH & SCIENCE UNIVERSITY;THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人:
VANDENBARK, ARTHUR A.,BURROWS, GREGORY G.,MEZA-ROMERO, ROBERTO,BENEDEK, GIL,ANDREW, SHAYNE,MOONEY, JEFFERY
申请号：
CA2860678
公开号：
CA2860678A1
申请日:
2013.01.04
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Disclosed herein are isolated major histocompatibility complex (MHC) class II al domain polypeptides and methods of use. In some embodiments, the isolated polypeptide comprises or consists of an MHC class H al domain polypeptide (or portion thereof) and does not include an MHC class II a2, ß1, or ß2 domain. The disclosed MHC class H al domain polypeptides are of use in treating or inhibiting disorders in a subject, such as inflammatory and/or autoimmune disorders. Also disclosed are methods of evaluating efficacy of treatment or optimizing treatment of a subject with a polypeptide including an MHC class II al domain polypeptide (or portion thereof) or a polypeptide including an MHC class II al domain and ß1 domain (such as a ß1a1 RTL).
