The present invention relates to the use of a morpholino compound having thegeneral formula: (I) wherein R1 is a straight or branched alkyl groupcontaining 8 to 16 carbon atoms at the 2- or 3-position of the morpholinoring, and R2 is a straight or branched alkyl group containing 2 to 10 carbonatoms, substituted with a hydroxy group except in the alpha-position, orpharmaceutically acceptable salts thereof, in the manufacture of a compositionfor the treatment of acne.