ВАН ТОЛ Эрик А.Ф. (NL),ГРОСС Габриеле (NL),БРАКСМА Матхтелт (NL),ОВЕРКАМП Карин М. (NL),ПОЭЛС Эдуард К. (US)
申请号：
RU2014137188
公开号：
RU2014137188A
申请日:
2013.03.18
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. Composition for the treatment or prevention of infection caused by a pathogen, containing the culture supernatant of the late exponential growth phase of the process of periodic cultivation of probiotic. The composition of claim 1, wherein the probiotic is LGG. 3. The composition of claim 1, wherein the pathogen is C. sakazakii. 4. The composition of claim 1, wherein the batch cultivation is carried out in a culture medium free of polysorbates. The composition of claim 4, wherein said medium contains an ingredient selected from the group consisting of oleic acid, linseed oil, olive oil, rapeseed oil, sunflower oil, and mixtures thereof. The composition according to claim 1, which contains a prenatal mixture, infant formula for infants or children, or a food composition or additive, therapeutic nutrition or food for special medical purposes. A composition for use in the treatment or prophylaxis of a pathogenic infection, obtained by a method comprising the steps of (a) cultivating a probiotic in a suitable culture medium using a batch process； (b) collecting the culture supernatant of the late exponential growth phase of the culturing stage, said phase is determined based on the second half of the time between the lag phase and the stationary phase of the batch cultivation process； (c) optionally removing components with a low molecular weight from the supernatant, so that components with a molecular weight above 5 kDa remain； (d) removing liquid contents from the culture supernatant to obtain a composition. The composition of claim 7, wherein the probiotic is LGG and the pathogen is C. sakazakii. 9. The composition of claim 8, wherein the late exponential phase is defined1. Композиция для лечения или профилактики инфекции, вызванной патогеном, содержащая культуральный супернатант поздней экспоненциальной фазы роста процесса периодического культивирования пробиотика.2. Композиция по п. 1, где пробиотиком является LGG.3. Композиция по п. 1, где патогеном является C
