mullerian inhibiting substance proteins (mis) and their uses for treating diseases

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专利权人:

MASSACHUSETTS EYE AND EAR INFIRMARY;THE GENERAL HOSPITAL CORPORATION

发明人:

David PEPIN,Demetrios VAVVAS,Mien Van HOANG,Patricia K. DONAHOE

申请号：

BR112015022181

公开号：

BR112015022181A8

申请日:

2014.03.12

申请国别(地区):

BR

年份:

2018

代理人:

摘要：

Summary of the patent for: â € œMullerian inhibition substance (mis) proteins and uses thereof for disease treatmentâ €. The present invention relates to modified recombinant human mis protein which has improved cleavage, bioactivity and potency compared to wild type human mis protein. Other aspects of the invention relate to methods for preventing and treating cancers, such as cancers expressing the mis receptor type II (misrii) by administering it to a subject. a composition comprising a recombinant human mis protein. Another aspect of the present invention relates to methods for reducing plasma androgen levels in an individual, and / or for treating an individual with a disease characterized by androgen excess. another aspect provides pharmaceutical compositions and kits and methods for use comprising a recombinant human mis protein. Another aspect of the present invention relates to methods for decreasing the dose of a chemotherapeutic agent by administering the chemotherapeutic agent with the recombinant protein, which decreases the effective dose of the chemotherapeutic agent.resumo da patente de invenã§ã£o para: “proteã�nas da substã‚ncia de inibiã‡ãƒo mulleriana (mis) e usos das mesmas para o tratamento de doenã‡asâ€�. a presente invenã§ã£o refere-se ã  proteã­na mis humana recombinante modificada, a qual possui clivagem, bioatividade e potãªncia aprimorados em comparaã§ã£o com a proteã­na mis humana tipo selvagem. outros aspectos da invenã§ã£o referem-se aos mã©todos para prevenir e tratar cã¢nceres, tais como cã¢nceres que expressam o receptor mis tipo ii (misrii) atravã©s da administraã§ã£o a um indivã­duo de uma composiã§ã£o que compreende uma proteã­na mis humana recombinante. outro aspecto da presente invenã§ã£o refere-se aos mã©todos para reduzir os nã­veis de andrã³geno plasmã¡ticos em um indivã­duo, e/ou para o tratamento de um indivã­duo com uma doenã§a caracterizada por excesso de andrã³geno. outro aspecto fornece composiã§ãµes farmacãªuticas e

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