An adhesive composition having dispersed therein a broad spectrumantimicrobialagent for use in medical applications, such as an adhesive for surgicaldrapes,wound dressings and tapes. The adhesive is composed of acrylic polymers,tackifiers and a antimicrobial agent, diiodomethyl-p-tolylsulfone. Theadhesivecomposition is essentially solventless and capable of application in a hotmeltprocess while maintaining stability at elevated temperatures in the range of275F. to350F., which not only allows hot melt application, but allows for ethyleneoxidesterilization under heat stress.