1. A nanoparticle comprising an inner sphere and the outer surface, the inner sphere contains a combination of conjugated drugs linked to stimuli sensitive bond and having a predetermined ratio, and conjugated drugs having the following formula: (XYZ) wherein: X is a pharmaceutically active agent Y is a linker sensitive to stimulus Z is not X, and is a pharmaceutically active agent or hydrogen n is an integral integer greater than or equal to 2 ikazhdaya combination of individual conjugated drug has a predetermined percentage of the molar mass of from about 1% to about 99%, with the proviso that the sum of the individual mole weight percent conjugated drug combination is 100% .2. A nanoparticle according to claim 1, characterized in that about 100% of the pharmaceutically active agents contained in the inner sphere, konyugirovany.3. A nanoparticle according to claim 1, characterized in that X is independently selected from the group consisting of an antibiotic, an antimicrobial agent, a growth factor, a chemotherapeutic agent, and kombinatsiy.4. A nanoparticle according to claim 1, characterized in that Z is independently selected from the group consisting of an antibiotic, an antimicrobial agent, a growth factor, a chemotherapeutic agent, hydrogen, and their kombinatsiy.5. A nanoparticle according to claim 1, characterized in that X is selected from the group consisting of doxorubicin, camptothecin, gemcitabine, carboplatin, oxaliplatin, epirubicin, idarubicin, carminomycin, daunorubits
