A method for assessing a broncho-dynamic response in a subject includes introducing a sound signal having known characteristics into the airway of a subject, detecting one or more responsive sound signals at one or more locations on the thorax, administering a broncho-effector to the subject, and determining the subject's response to the broncho-effector by monitoring the one or more responsive sound signals before and after administering the broncho-effector. Changes in the responsive sound signal characteristics indicate the subject's broncho-dynamic response to the broncho-effector. Apparatus for assessing broncho-dynamic response in a subject is also provided.