A delivery system for intranasally administering doses of a substance such as a drug, vaccine, or the like is provided. The drug delivery system includes a holder comprising a rear case and a pre-filled drug container that is securely connected to the holder. The drug container includes a cartridge for containing the drug, a movable stopper within the cartridge, and an end having an opening through which the substance within the cartridge can be expelled. The rear case is connected to the drug container at one end and an activator at the other end. Within the rear case is contained the means for activating the movable stopper within the cartridge, which acts as a plunger rod, by pressing the activator. Further provided is a nozzle able to be attached to the opening at the end of the drug container to provide a means for precise delivery of the drug.
