A device (1) for loading and unloading isothermal containers for transporting foodstuffs consists of a support structure (6) configured to be installed on the bottom (P) of an isothermal container (C) to autonomously operate the inlet and outlet of a wheeled basket (B) conventionally employed for handling the foodstuffs. The support structure (6) is horizontally displaceable along guides (2), having a stationary section (3) and a movable section (4), between a retracted position and an extracted position relative to the isothermal container (C), and it bears a fork platform (7) vertically displaceable, in the extracted position of the support structure (6), between a lowered position and a raised position.