Selected compounds of formula (I) are effective for prophylaxis and treatmentof diseases, such as VEGF mediated diseases. The invention encompasses novelcompounds, analogs, prodrugs and pharmaceutically acceptable salts thereof,pharmaceutical compositions and methods for prophylaxis and treatment of diseasesand other maladies or conditions involving, cancer and the like. The subjectinvention also relates to processes for making such compounds as well as to intermediatesuseful in such processes.