Subject of the present invention is a pharmaceutical composition comprising (a) desPro36Exendin-4(1-39)Lys6- NH2 or/and a pharmaceutically acceptable salt thereof, and (b) insulin glargine or/and a pharmaceutically acceptable salt thereof.本發明之主題係關於一種醫藥組成物包含(a) desPro36艾塞那肽-4(1~39)Lys6-NH2或/及其醫藥上可接受鹽;以及(b)甘精胰島素或/及其醫藥上可接受鹽。