COMPOSITIONS, PRODUITS PHARMACEUTIQUES CONDITIONNES, ET METHODES D'UTILISATION DE MODULATEURS DE LA VOIE HEDGEHOG POUR LA SENSIBILISATION DE TUMEURS RESISTANTES

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专利权人:

BHAGWANDIN; VIKASH J.

发明人:

BHAGWANDIN, VIKASH J.

申请号：

CA3001831

公开号：

CA3001831A1

申请日:

2016.10.12

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

Compositions, packaged pharmaceuticals, and methods of treatment by the sensitization of resistant tumors are provided. The compositions comprise a combination of a hedgehog pathway modulator, such as itraconazole, and a chemotherapeutic agent. Tumor cells in mammalian subjects treated with the hedgehog pathway modulator are sensitized to the effects of the chemotherapeutic agent, thus increasing the therapeutic index of the agent and reducing toxicity to the subject.

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