Prevention of pertussis using adenylate cyclase deficient Bordetella strains

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专利权人:

Institut Pasteur de Lille;Institut National de la Santé et de la Recherche Médicale (INSERM);National University of Singapore

发明人:

Sylvie Claudette Alonso,Rui Fen Annabelle Lim,Camille Locht

申请号：

US15477562

公开号：

US10046044B2

申请日:

2017.04.03

申请国别(地区):

US

年份:

2018

代理人:

摘要：

A CyaA-deficient B. pertussis mutant was constructed and used in a vaccine. The pertussis-specific antibody profile and Th17 response induced by vaccination with the mutant was surprisingly comparable to that induced by B. pertussis strains not deficient in CyaA.

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