CLARKE, ADAM, WILLIAM,DOYLE, ANTHONY GERARD,JENNINGS, PHILIP, ANTHONY,POULTON, LYNN, DOROTHY,WAI, BERNADETTE,POW, ANDREW, JAMES,KOPSIDAS, GEORGE
申请号：
EP09806241
公开号：
EP2326668A4
申请日:
2009.08.14
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The present invention provides an antibody comprising an antigen binding domain which binds to human IL-12 and human IL-23. The antibody binds human IL-12p40 existing as a monomer (human IL-12p40) and as a homodimer (human IL-12p80) and the antibody inhibits the binding of human IL-12 to human IL-12R beta2 and human IL-23 to human IL-23R but does not inhibit the binding of human IL-12 or human IL-23 or human IL-12p40 or human IL-12p80 to human IL-12Rbeta1.
