ANTI-INFLAMMATORY COMPOSITION CONTAINING CARYOPTERIS INCANA FERMENTED EXTRACT FERMENTED IN SOLID USING LACTIC ACID BACTERIA AS ACTIVE INGREDIENT, AND PRODUCING METHOD THEREOF
경북대학교 산학협력단;KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
YOUNG JE CHO,조영제,PARK MI JEONG,박미정
申请号：
KR1020200030974
公开号：
KR1020200030523A
申请日:
2020.03.12
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention relates to an anti-inflammatory composition comprising, as an active ingredient, a Caryopteris incana extract with an increased inflammation-inhibiting effect by being fermented with lactic acid bacteria, and to a producing method thereof. Inventors of the present invention have confirmed that the Caryopteris incana extract fermented with lactic acid bacteria effectively suppresses the inflammatory reaction of cells and has low cell toxicity compared to a non-fermented Caryopteris incana extract since the Caryopteris incana extract fermented with lactic acid bacteria, Lactobacillus plantarum, reduces the expression of inflammatory mediators induced from Raw 264.7 cells to lipopolysaccharide (LPS). Therefore, the present invention is expected to be able to secure excellent herbal resources with high productivity of pharmacologically active compounds by establishing a fermentation system, reducing the toxicity of Caryopteris incana, and increasing an inflammation-inhibiting activity, and the solid fermentation extract of Caryopteris incana can be useful as an anti-inflammatory health functional food composition and an excellent material for developing a new inflammatory agent.COPYRIGHT KIPO 2020본 발명은 젖산균 (Lactobacillus plantarum)으로 발효되어 염증 억제효과가 증가된 층꽃나무 추출물을 유효 성분으로 함유하는 항염증용 조성물 및 그 제조방법 등에 관한 것으로, 본 발명자들은 젖산균 (Lactobacillus plantarum)으로 발효시킨 층꽃나무 추출물이 Raw 264.7 cell에서 lipopolysaccharide (LPS)로 유도된 염증매개물질의 발현을 감소시킴으로써 세포의 염증반응을 효과적으로 억제하고, 비발효 층꽃나무 추출물에 비하여 세포독성이 낮음을 확인하였다. 따라서 본 발명에 따라 발효시스템을 확립함으로써 층꽃나무의 독성을 감소시키고 염증억제활성을 증대시켜 약리활성 화합물의 생산성이 높은 우수한 한방자원을 확보할 수 있을 것으로 기대되며, 층꽃나무 고체 발효 추출물은 새로운 항염증제 개발을 위한 우수한 소재 및 염증 개선용 건강기능식품 조성물로 유용하게 사용될 수 있다.
