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Small liposomes for delivery of immunogen-encoding RNA
专利权人:
Novartis AG
发明人:
Geall, Andrew,Verma, Ayush
申请号:
AU2018204178
公开号:
AU2018204178A1
申请日:
2018.06.12
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
#$%^&*AU2018204178A120180705.pdf#####ABSTRACT Nucleic acid immunisation is achieved by delivering RNA encapsulated within a liposome. The RNA encodes an immunogen of interest, and the liposome has a diameter in the range of 60-180nm, and ideally in the range 80-160nm. Thus the invention provides a liposome having a lipid bilayer encapsulating an 5 aqueous core, wherein: (i) the lipid bilayer has a diameter in the range of 60-180nm; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases.
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