Small liposomes for delivery of immunogen-encoding RNA

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专利权人:

Novartis AG

发明人:

Geall, Andrew,Verma, Ayush

申请号：

AU2018204178

公开号：

AU2018204178A1

申请日:

2018.06.12

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

#$%^&*AU2018204178A120180705.pdf#####ABSTRACT Nucleic acid immunisation is achieved by delivering RNA encapsulated within a liposome. The RNA encodes an immunogen of interest, and the liposome has a diameter in the range of 60-180nm, and ideally in the range 80-160nm. Thus the invention provides a liposome having a lipid bilayer encapsulating an 5 aqueous core, wherein: (i) the lipid bilayer has a diameter in the range of 60-180nm； and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases.

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