The present invention provides the both-end Pegylation peptide conjugate of targeted integration element such as 6 integrins of β-β. One of in specific embodiments, peptide conjugate of the invention further comprises biological agent, such as preparation or therapeutic agent, such as be covalently attached to peg moiety. Peptide conjugate of the invention is especially suitable for being imaged tumour, organ or tissue, and disease and disease for treating mediated by integrin, such as cancer, diseases associated with inflammation, autoimmune disease, chronic fibrosis, chronic obstructive pulmonary disease (COPD), lung em etc.. Plant and chronic injury dermatoses. Composition and kit comprising peptide conjugate of the invention have practicability in the extensive use including such as in-vivo imaging and immunization therapy.
