It is possible to estimate the activity of joint riumachi effectiveness of the anti- TNF antibody medicine for joint riumachi, after prescribing thing, and the aforementioned medicine where certainty is high, at the same time, estimates simply in addition, medicinal effect estimate method of the anti- TNF antibody medicine for joint riumachi which can evade the wasteful side effect by the fact that the medicine is prescribed to the case where the aforementioned medicine is effective more securely, and offer of the medicinal effect estimate device. Whether or not as for medicinal effect estimate method of the anti- TNF antibody medicine for joint riumachi of this invention, the content of process and the description above ADAMTS5 which measure the content of ADAMTS5 in the sample of suffering inspection body origin as an index, vis-a-vis joint riumachi the anti- TNF antibody medicine validity the process which is appraised and, it includes.関節リウマチに対する抗TNFα抗体薬の有効性を、確実性が高く、かつ、簡便に予測すること、及び前記薬を投与した後における関節リウマチの活動性を予測することができ、また、前記薬がより確実に効く症例に薬を投与することで無駄な副作用を回避することができる関節リウマチに対する抗TNFα抗体薬の薬効予測方法、及び薬効予測装置の提供。本発明の関節リウマチに対する抗TNFα抗体薬の薬効予測方法は、被検体由来の試料中のADAMTS5の含有量を測定する工程と、前記ADAMTS5の含有量を指標として、関節リウマチに対して抗TNFα抗体薬が有効か否かを評価する工程と、を含む。
