A fluid connection system and a method of attaching the same are provided to create a sterile fluid-flow path. The connection system includes a fluid access device having a female connector with a female elastomeric member disposed at a proximal end thereof and is coupled to an internal surface of the fluid access device. A male connector is coupled to an external surface of the female elastomeric member. Additionally, a male elastomeric member is disposed within the distal end of the male connector and seals a distal opening thereof. At least one aperture is disposed through a sidewall of the distal end of the male connector. An internal cannula is exposed out of the female connector to open the female elastomeric member upon engagement with the male connector. The male connector is sealed to the female connector by the male elastomeric member.
