БРИТО Луис (US),ДЖИЛЛ Эндрю (US),О'ХЕЙГАН Дерек (US),СИНГХ Манмохан (US),ОХЕЙГАН Дерек (US)
申请号：
RU2013104870/15
公开号：
RU2013104870A
申请日:
2011.07.06
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A composition comprising an RNA molecule in combination with a particle of an oil-in-water cationic emulsion, wherein the particle contains (a) an oil core in the liquid phase at 25 ° C, and (b) a cationic lipid. The composition according to PP. 1, where the particle further comprises a surfactant. 3. The composition of claim 2, wherein the surfactant is a nonionic surfactant. The composition of claim 3, wherein the surfactant is sorbitan trioleate, polysorbate 80, or a combination thereof. A composition according to claim 3, wherein the oil-in-water cationic emulsion contains from about 0.01% to about 2.5% (v / v) of a nonionic surfactant. A composition according to claim 1, wherein the composition comprises from about 0.2% to about 9% (vol./about.) Of said oil. The composition of claim 1, wherein the oil core comprises soybean oil, sunflower oil, olive oil, squalene, squalane, and a combination thereof. The composition of claim 1, wherein the cationic lipid is selected from the group consisting of 1,2-dioleoyloxy-3- (trimethylammonio) propane (DOTAP), 3β- [N- (N ', N'-dimethylaminoethane) carbamoyl] cholesterol (DC cholesterol), dimethyldioctadecylammonium (DDA), 1,2-dimyristoyl-3-trimethylammonium-propane (DMTAP), dipalmitoyl (C) trimethylammonium-propane (DPTAP), distearoyltrimethylammonium-propane (DSTAP), 2- [1- 3-dioleyloxy) propyl] -N, N, N-trimethylammonium (DOTMA), N, N-dioleoyl-N, N-dimethylammonium chloride (DODAC), 1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (DOEPC) and 1,2-dioleoyl-3-dimethylammonium propane (DODAP), 1,2-dilinoleilo B-3-dimethylamino propane (DLinDMA) .9. The composition of claim 1, wherein the cationic lipid is 1,2-dioleoyloxy-3- (trimethylammonio) propane (DOTAP), and the oil-in-water cationic emulsion contains from1. Композиция, содержащая молекулу РНК в комплексе с частицей катионной эмульсии "масло-в-воде", где частица содержит (a) масляное ядро, находящееся в жидкой фазе при 25°C, и (b) катионный липид.2. Композиция по пп. 1
