Her Majesty the Queen in Right of Canada as Represented by the Minister of Health
发明人:
Ma Luo
申请号：
US16810441
公开号：
US20200246269A1
申请日:
2020.03.05
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Instead of generating immune responses to several HIV proteins and risk over activating more CD4+ T cells (easy targets for HIV-1 infection) as current candidate vaccines try to do, a lower magnitude, narrowly focused, well maintained virus specific CD8+ T cell response to multiple subtypes should destroy and eliminate a few founder viruses without inducing inflammatory responses that may activate more CD4+ T cells and provide more targets for HIV-1 virus infection. Specifically, described herein is a method that focuses the immune response to the 12 protease cleavage sites.
