The present invention relates to a composition for oral use, in particular in form of food supplement comprising quercetin, extract of curcuma or curcumin, feverfew extract and a preparation comprising omega-3 and/or omega-6 and optionally nicotinamide and/or 5-methyltetrahydrofolate calcium salt. Moreover, the present invention relates to the use of such composition for the treatment of endometriosis symptoms and in reducing endometriosis outbreaks.