The present invention disclose crystal forms I, II, III and IV of compound 5-3 used for orexin receptor resist, and preparation thereof, and also relates to their applications in preparation of medicine for curing orexin-relative diseases.本發明公開了作爲食慾素受體阻抗劑化合物5-3的Ⅰ晶型、Ⅱ晶型、Ⅲ晶型和Ⅳ晶型及其製備方法,並涉及其在製備治療與食慾素有關疾病的藥物中的應用。