A COMPOSITION COMPRISING 2,4,6,8-TETRAKIS (2-METHOXYPHENYL)-3,7-DIAZABICYCLO[3.3.1] NONAN-9-ONE AS AN ACTIVE INGREDIENT FOR TREATING AND PREVENTING CANCER DISEASE
INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;인제대학교 산학협력단
发明人:
KIM, DONG KYOO,김동규,JUNG, JEE HYUNG,정지형,PARK, DONG HO,박동호,PARAMASIVAM PARTHIBAN,파라마시밤 파르티반,XIN ZHANG,장 신,HWANG, JI YOUNG,황지영,YI, MYEONG JIN,이명진
申请号：
KR1020110113167
公开号：
KR1020130048355A
申请日:
2011.11.02
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A composition containing 2,4,6,8-tetrakis (2-methoxyphenyl)-3,7-diazabicyclo&lsqb；3.3.1&rsqb； nonan-9-one for preventing and treating cancer is provided to induce cancer cell apoptosis. CONSTITUTION: A composition for preventing and treating cancer contains 2,4,6,8-tetrakis (2-methoxyphenyl)-3,7-diazabicyclo&lsqb；3.3.1&rsqb； nonan-9-one of chemical formula 1, or a pharmaceutically acceptable salt, an optical isomer, a stereomer, and a polymorph thereof as an active ingredient. The cancer includes uterine cervix cancer, colon cancer, anal cancer, esophageal cancer, pancreatic cancer, stomach cancer, kidney cancer, tongue cancer, oral cancer, skin cancer, uterine cancer, breast cancer, lymph gland cancer, thyroid cancer, prostate cancer, liver cancer, leukemia, skin cancer, colon carcinoma, brain tumor, bladder cancer, ovarian cancer, or gallbladder cancer. The composition induces cancer cell apoptosis. The composition suppresses DNA synthesis and causes oxidative stress. The composition includes apoptosis through mitochondrial membrane depolarization.본 발명은 암 예방 및 치료용 조성물 및 이를 포함하는 건강기능식품에 관한 것으로, 보다 상세하게는 2,4,6,8-테트라키스-(2-메톡시페닐)-3,7-디아자바이시클로[3.3.1]노난-9-원(2,4,6,8-tetrakis(2-methoxyphenyl)-3,7-diazabicyclo[3.3.1] nonan-9-one), 약학적으로 허용 가능한 그의 염, 광학이성질체, 또는 다형체를 유효성분으로 포함하는 암 예방 및 치료용 조성물 및 이를 함유하는 건강기능식품에 관한 것이다.본 발명의 화합물들은 미토콘드리아의 탈분극을 유도하며, DNA 합성을 저해하고, 조기 세포 사멸을 발생시켜 세포사멸(apoptosis)을 유도하고, 세포 성장의 저해를 나타냄으로서, 암세포의 세포사멸(apoptosis)을 유도하기 때문에 암 질환의 예방 및 치료에 유용하게 사용될 수 있다.
