A pacifier holder box includes a box body (10), and an upper cover (11) covering the box body. The upper cover is provided with a basin (112) having an end face (111). The box body has an interior provided with a receiving recess (12) and has an exterior provided with a hanging hook (13) extending outward. The hanging hook of the box body has an upper end provided with a locking portion (131) and a distal end provided with a hooking portion (132). The box body has a back face provided with an inclined guide face (14) facing the hooking portion of the hanging hook. A passage (15) is defined between the guide face of the box body and the hooking portion of the hanging hook.