SUPURAN CLAUDIU,DEDHAR SHOUKAT,MCDONALD PAUL C,CARTA FABRIZIO
申请号：
IN1210/DELNP/2013
公开号：
IN2013DN01210A
申请日:
2013.02.07
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
222n2610Therapeutic sulfonamide compounds with the formula R Q Ar SONH are disclosed wherein R is an aryl hetaryl alkyl or cycloalkyl group Q is the group L(CH) wherein n = 0 1 or 2 and L is the group NHCXNH NHC(S)SNH NHCONHCSNH or SONH X is O or S and Ar is a C C aromatic or a heteroaromatic group that contains at least one heteroatom of oxygen nitrogen or sulphur which compounds selectively inhibit CAIX and CAXII and which are effective in inhibiting hypoxic tumor growth suppress metastases and impair and deplete cancer stem cells in mammals.
