#$%^&*AU2018202210A120180426.pdf#####C: NRPortbl DCC REC 4881025_1.DOC-1/23/2013 ABSTRACT The present invention relates uses of an S1 P receptor modulator such as 2-substituted 2amino- propane-1,3-diol or 2-amino-propanol derivatives, e.g. a compound comprising a group of formula (X) z R3zR 2zN CH2R 1 (X) for the treatment or prevention of neo-angiogenesis associated with a demyelinating disease, e.g. multiple sclerosis.