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Pyrrolyl substituted dihydroindol-2-one derivatives, preparation methods and uses thereof
专利权人:
Jingyi Wang
发明人:
Jingyi Wang,Chuanwen Fan,Long Zhang,Boyan Xu,Shousheng Yan,Zongru Guo,Minghui Zhang,Dong Lin,Zhantao Zhang,Haojie Zhou
申请号:
US13702956
公开号:
US08637681B2
申请日:
2011.03.31
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Provided are pyrrolyl substituted dihydroindol-2-one derivatives represented by formula (I), pharmaceutically acceptable salts or solvates of said derivatives, or solvates of said salts, which are effective tyrosine kinase inhibitors. Also provided are the preparation methods of the above compounds, pharmaceutical compositions containing these compounds, and the use of these compounds in manufacturing drugs useful for the treatment or adjunctive treatment of tumors medicated by tyrosine kinases or proliferation or migration of tumor cells driven by tyrosine kinases in mammals (including human).
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