A telemedical interface pressure monitoring system is provided for intermittent or continuous monitoring of the pressure that occurs at the interface between the body and a support surface such as with a compression device, cast or resting surface. The system simultaneously measures interface pressure at multiple compression positions as well as provide real-time measurement data to both patients and clinicians. The system uses an array of one or more sensors and a data collection and transmission node with a microprocessor and transmitter/receiver that transmits the sensor data to a receiver such as a mobile device or cloud or clinic server for remote display, evaluation and automatic recording. Remote receivers can also control compression devices associated with the node.