INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 15 November 2018 (15.11.2018) WIPO I PCT ~~ll~~~~~~~~ 011101VIIIVIIIVIII olo oi olo Imo ow (10) International Publication Number WO 2018/209205 Al (51) International Patent Classification: A61K 31/436 (2006.01) A61K 38/46 (2006.01) A61K 38/13 (2006.01) Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (21) International Application Number: PCT/US2018/032278 (22) International Filing Date: 11 May 2018 (11.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/504,817 11 May 2017 (11.05.2017) US 62/599,816 18 December 2017 (18.12.2017) US 62/652,006 03 April 2018 (03.04.2018) US (71) Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]； 3160 Chestnut Street, Suite 200, Philadelphia, PA 19104 (US). (72) Inventors: WILSON, James, M.； 1831 Delancey Street, Philadelphia, PA 19103 (US). KATZ, Nathan； 1111 Hope Street, Unit 3, Stamford, CT 06907 (US). HINDERER, Christian； 212 Brown Street, Apt. 8A, Philadelphia, PA 19123 (US). HORDEAUX, Juliette； 712 S. Mildred Street, Philadelphia, PA 19147 (US). (74) Agent: SCHALLER, Colleen, M. et al.； Howson & How- son LLP, 350 Sentry Parkway, Building 620, Suite 210, Blue Bell, PA 19422 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG,
