Carl Alexander Kamb,Helen Y. Kim,Sungeun Kim,William Christian Fanslow, III
申请号：
US14466844
公开号：
US20150201588A1
申请日:
2013.02.22
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed is an autologous non-human mammalian model system derived from induced pluripotent stem (iPS) cells. Also disclosed are methods of differentiating non-human primate iPS cells, which can result in populations of cells enriched for SOX2+ or PDX1+ foregut-like cells, for CDX2+ hindgut-like cells, for CD34+ hematopoietic progenitor-like cells, or epithelial-like cells. Also disclosed is a non-human primate containing an autologous cell type of interest, which is differentiated in vitro from an induced pluripotent stem cell reprogrammed from a primary somatic cell. Methods of monitoring exogenously introduced cells within a non-human mammal are also disclosed.
