An embodiment in the MRI-CEST field is proposed for analyzing a body-part, which includes a CEST agent providing a magnetization transfer with a bulk substrate of the body-part. A corresponding diagnostic system includes input means for providing an input map including a plurality of input elements each one for a corresponding location of the body-part each input element is indicative of a spectrum of a magnetic response of the location, which spectrum includes the magnetic response at an agent frequency of resonance of the contrast agent (with the agent frequency that is at an agent offset of frequency from a bulk frequency of resonance of the bulk substance), and at a reference frequency at the opposite of the agent offset from the bulk frequency. The system further includes calculation means for calculating an agent value and a reference value for each one of a set of selected locations the agent value is calculated according to the magnetic responses of the selected location in a non-punctual agent range of frequencies including the agent frequency, and the reference value is calculated according to the magnetic responses of the selected location in a non-punctual reference range of frequencies including the reference frequency (with the reference range that is symmetric to the agent range with respect to the bulk frequency). Comparison means is then provided for calculating a parametric value for each selected location the parametric value is calculated according to a comparison between the agent value and the reference value of the selected location.
