PROBLEM TO BE SOLVED: To provide a pharmaceutical composition excellent in safeness, having an excellent pharmacological effect and suppressing gastrointestinal tract disturbance caused by loxoprofen or its salt.SOLUTION: The pharmaceutical composition contains loxoprofen or its salt, an antihistamine agent and ephedrines. Preferably, the loxoprofen or its salt is a loxoprofen sodium hydrate.COPYRIGHT: (C)2012,JPO&INPIT【課題】優れた薬理作用を有する医薬組成物の提供。【解決手段】ロキソプロフェン又はその塩、抗ヒスタミン剤及びエフェドリン類を含有する医薬組成物。【選択図】なし