PROBLEM TO BE SOLVED: To provide a vesicle composition excellent in storage stability.SOLUTION: A production method of a vesicle composition in which an aqueous phase is used as a continuous phase, uses an oil phase including following components, a component (A): a fatty acid having totally 12 to 40 carbon atoms, a component (B): a tertiary amine compound having totally 8 to 75 carbon atoms, a component (C): an organic acid having totally 1 to 10 carbon atoms, and a component (D): a first polyhydric alcohol, and comprises: an oil phase preparation step which dissolves the oil phase at a temperature equal to or higher than the melting point of the oil phase an emulsification step which mixes the oil phase obtained by the oil phase preparation step while adding the aqueous phase thereto an addition step which adds a component (D): a second polyhydric alcohol to the oil phase when the amount of the aqueous phase added to the oil phase becomes 1 mass times to the oil phase or more and a cooling step which cools the obtained composition after the emulsification step.COPYRIGHT: (C)2014,JPO&INPIT【課題】保存安定性に優れたベシクル組成物を提供する。【解決手段】以下の成分(A)~(D):成分(A);総炭素数12~40の脂肪酸、成分(B);総炭素数8~75の第3級アミン化合物、成分(C);総炭素数1~10の有機酸、および成分(D);第一の多価アルコールを含有する油相を、当該油相の融点以上の温度で溶解させる油相調製工程、該油相調製工程で得られた油相に水相を加えながら混合する乳化工程、該油相に添加した該水相の量が該油相の1質量倍以上になった後、成分(D);第二の多価アルコールを加える添加工程、ならびに該乳化工程の後、得られた組成物を冷却する冷却工程を含む、連続相が水相であるベシクル組成物の製造方法。【選択図】なし
