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Novel antigen binding proteins and their use as addressing products (ADDRESSINGPRODUCT) for the treatment of cancer
专利权人:
ピエール、ファーブル、メディカマン
发明人:
シャルロット、ボー-ラルボール,リリアンヌ、ゲシュ,ニコラ、ブーテ,シャルロット、ボー-ラルボール
申请号:
JP2015540158
公开号:
JP6445444B2
申请日:
2013.11.05
申请国别(地区):
JP
年份:
2018
代理人:
摘要:
The present invention relates to novel antigen binding proteins, in particular monoclonal antibodies, capable of binding to the protein Axl as well as the amino and nucleic acid sequences coding for said proteins. From one aspect, the invention relates to novel antigen binding proteins, or antigen binding fragments, capable of binding to Axl and, by inducing internalization of Axl, being internalized into the cell. The invention also comprises the use of said antigen binding proteins as addressing products in conjugation with other anti-cancer compounds, such as toxins, radio-elements or drugs, and the use of same for the treatment of certain cancers.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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