The present disclosure provides thermosetting biophotonic compositions and methods useful in phototherapy. In particular, the thermosetting biophotonic compositions of the present disclosure include block copolymer and at least one chromophore solubilized in the block copolymer. The thermosetting biophotonic compositions and the methods of the present disclosure are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various other skin disorders.本發明提供在光電療法中有用之熱固性生醫光電組合物及方法。特定言之,本發明之熱固性生醫光電組合物包含嵌段共聚物及至少一溶解於該嵌段共聚物中之發色團。本發明之熱固性生醫光電組合物及方法對促進傷口癒合及皮膚回春,及治療痤瘡及各種其他皮膚疾病係有用的。