The composition of the present invention comprisingCucurbita moschata, Carthamus tinctorius, Plantago asiaticaand Lonicera japonica has a follicle-stimulating hormonereduction action. Based on this action, the composition isusable as a preventive, remedy, health food or functionalfood for diseases, for example, climacteric disturbance,primary hypogonadism (including ovarian hypofunction andtesticular deficiency), Turner's syndrome, Klinefelter'ssyndrome, gonadotropin-producing tumor, testitis, and primaryovarian amenorrhea and/or hormone-producing tumor.
