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Antibacterial and antiviral peptides from Actinomadura namibiensis
专利权人:
Sanofi
发明人:
Seibert, Gerhard,Vertesy, Laszlo,Meindl, Kathrin,Hoffmann, Holger,Toti, Luigi,Sussmuth, Roderich,Wink, Joachim,Broenstrup, Mark,Sheldrick, George,Winkler, Irvin,Guehring, Hans
申请号:
AU2007304536
公开号:
AU2007304536B2
申请日:
2007.09.25
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The invention refers to of a compound of the formula (I) wherein R3 and R4 are independentlyH or OH, and wherein m and n are independently of one another 0, 1 or 2, obtainablefrom Actinomadura namibiensis (DSM 6313), its use for the treatment of bacterialinfections, viral infections and/or pain, and pharmaceutical compositioncomprising it. The compounds of formula (I) have been defined as labyrinthopeptinsand consist of a highly bridged peptidic structure of 18 amino acids containinglanthionine-like residues and alpha disubstituted amino acid analogues. Theamino acid sequence is XDWXLWEXCXTGXLFAXC, wherein the two Cys residues forma disulfide bridge and each X independently represents one of the non-naturalamino acids involved in the bridging linkages.
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