Childrens Medical Center Corporation;Children's Medical Center Corporation
发明人:
Lu, Yingjie,Zhang, Fan,Malley, Richard
申请号：
AU2014214844
公开号：
AU2014214844B2
申请日:
2014.02.07
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The present application is generally directed to novel pneumococcal polypeptide antigens and nucleic acids encoding such antigens, and immunogenic compositions comprising such antigens for treating and preventing pneumococcal infection. The present invention further provides method of using the antigens to elicits an immune response (e.g., IL-17A response, a T cell-mediated and/or B-cell-mediated immune responses). The present invention also provides methods of prophylaxis and/or treatment of pneumococcal-mediated diseases, such as sepsis, comprising administering an immunogenic composition including one or more of a combination of pneumococcal antigens or functional fragments thereof as disclosed herein. In some embodiments, one or more pneumococcal antigens can be present in a polysaccharide conjugate. The compositions induce an anti-pneumoccocus immune response when administered to a mammal. The compositions can be used prophylactically to vaccinate an individualand/or therapeutically to induce a thereapeutic immune response to an infected individual.
