Patrick J. Hrdlicka,Pawan Kumar,Michael E. Østergaard
申请号：
US13416906
公开号：
US20120295862A1
申请日:
2012.03.09
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Embodiments are disclosed herein that involve C5-functionalized nucleic acids, which can be used for detecting a target in a nucleic acid. Particular embodiments disclose methods for making these compounds, wherein the compounds can be formed by coupling of an intermediate with a linker. Certain embodiments disclose the use of these compounds for detecting single nucleotide polymorphisms, and for increasing the thermal affinity of nucleic acid complements as compared to unmodified nucleic acid complements. In addition, the disclosed compounds can decrease enzymatic degradation of nucleic acids.
