CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS

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专利权人:

IMMUNOGEN; INC.

发明人:

HARRIS, LUKE, B.,TAVARES, DANIEL,RUI, LINGYUN,FISHKIN, NATHAN, ELLIOTT,SHIZUKA, MANAMI,MILLER, MICHAEL, LOUIS,CHARI, RAVI, V.J.

申请号：

SG11201701565P

公开号：

SG11201701565PA

申请日:

2015.09.02

申请国别(地区):

SG

年份:

2017

代理人:

摘要：

The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an aldehyde group obtained from oxidation of a 2-hydroxyethylamine moiety on the CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/